Production of the second-generation Stout started in July 1960. Seeing that the "flat-deck styling" featuring a flat-top hood had been rapidly becoming prevalent in the United States since around 1958, Toyota went ahead and introduced this design to the Stout even before the style was adopted by domestic passenger cars, giving the truck a distinctly modern look. The curved glass windshield wrapped around the front corners, eliminating the vent windows. The vehicle length and width were extended to the limits of the small car category to make the interior more spacious, while the maximum payload capacity remained the same at 1,750 kg. The quality of the frame and brakes was improved, and a hypoid gear was adopted for the differential to lower the floor and center of gravity, as well as to improve the power transmission efficiency.

The model variations included a single cab truck (RK45, payload capacity: 1.75 tons), a double cab truck (RK45P, 1 ton), and a light van (RK45V, 1 ton). The light van featured one door on the right and two on the left for practical reasons. Stimulated by the increased competitiveness of the Stout, Nissan fully redesigned its Junior truck in January 1961 and added a 2-ton version with a 1,900 cc engine. In response, Toyota introduced a 2-ton model (RK100) fitted with a 1,900 cc 80 hp 3R-B engine and four headlamps. A minor model change of the Stout in 1967 replaced all its engines with a 2,000 cc 5R unit, and the model subname was changed to the RK101.

At the same time, the model name was changed from Toyopet Stout to Toyota Stout.